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Tuberculosis P3 laboratory

BARC laboratories are proud to showcase their new Mycobacterium Tuberculosis (TB) P3 laboratory. This new laboratory’s features now enable more rapid and accurate diagnosis of Mycobacterium Tuberculosis, and ensures the safety of all staff members working in and around the TB lab; working together to protect the staff and the community from the scourge of TB.

Features of Tuberculosis P3 Laboratory

Screening:

  • Auramine stain - Ziehl Neelsen stain (ZN) used as confirmatory stain for positive Auramine samples
  • Sputum assessment with ZN stain possible for BARC clinical trial samples only

Culture capacity:

  • MGIT and Lowenstein Jensen Media - BARC Clinical Trials only

Methods of Identification available:

  • Rapid chromatographic Immunoassay for qualitative detection of MTB complex Antigen from culture.
  • GeneExpert: semi quantitative nested real time PCR detection of MTB complex DNA - Rapid testing, test time of 1hr 55 mins; smear negative samples can be used.
  • Gen-probe : Nucleic Acid hybridisation Identification from culture: Gen-probe Accuprobe culture identification test for Mycobacterium Tuberculosis, Mycobacterium Avium, Mycobacterium Kansassii and Mycobacterium Intracellular.
  • Hains MTBDR Plus: PCR Reverse hybridisation line probe strip assay Identification of Mycobacterium Species and Drug Resistance to INH and RIF on MTB; smear positive and culture samples can only be used.
  • Lowenstein Jensen Media - BARC Clinical Trials only

TB Sensitivity on culture samples using GenProbe methodology:

  • First-line - Rifampicin, INH, Ethambutol, Streptomycin, PZA
  • Second-line - Ofloxacin/moxifloxacin, Kanamycin, Ethionamide

TB Resistance testing on sputum samples for screening for MDR / XDR initially:

  • GeneExpert : PCR - RIF (smear positive and smear negative samples)
  • Hains : PCR - RIF and INH (smear positive samples only)

Resistance testing on cultures:

  • MGIT - DST Full first line and second line sensitivity testing if required

Quantiferon Elisa Test:

  • Differentiates TB infection from BCG and TB infection from nearly all non-TB Mycobacterial infections, but does not differentiate between latent and active disease.
  • Results within 48 hours

If you would like further information about the TB facility please feel free to contact us.
 
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